Iowa Mutant Apolipoprotein A-I (ApoA-I(Iowa)) Fibrils Target Lysosomes

The single amino acid mutation G26R in human apolipoprotein A-I (apoA-I(Iowa)) is the first mutation that was associated with familial AApoA1 amyloidosis. The N-terminal fragments (amino acid residues 1–83) of apoA-I containing this mutation deposit as amyloid fibrils in patients’ tissues and organs...

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Udgivet i:Sci Rep
Main Authors: Kameyama, Hirokazu, Nakajima, Hiroyuki, Nishitsuji, Kazuchika, Mikawa, Shiho, Uchimura, Kenji, Kobayashi, Norihiro, Okuhira, Keiichiro, Saito, Hiroyuki, Sakashita, Naomi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4964564/
https://ncbi.nlm.nih.gov/pubmed/27464946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30391
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