Apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides inhibit tumor development in a mouse model of ovarian cancer

We examined whether reduced levels of Apolipoprotein A-I (apoA-I) in ovarian cancer patients are causal in ovarian cancer in a mouse model. Mice expressing a human apoA-I transgene had (i) increased survival (P < 0.0001) and (ii) decreased tumor development (P < 0.01), when compared with litte...

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Hauptverfasser: Su, Feng, Kozak, Kathy R., Imaizumi, Satoshi, Gao, Feng, Amneus, Malaika W., Grijalva, Victor, Ng, Carey, Wagner, Alan, Hough, Greg, Farias-Eisner, Gina, Anantharamaiah, G. M., Van Lenten, Brian J., Navab, Mohamad, Fogelman, Alan M., Reddy, Srinivasa T., Farias-Eisner, Robin
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2010
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993420/
https://ncbi.nlm.nih.gov/pubmed/21041624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009010107
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