MK-2206 sensitizes BRCA-deficient epithelial ovarian adenocarcinoma to cisplatin and olaparib

BACKGROUND: Platinum resistance is a major obstacle in the treatment of epithelial ovarian cancer (EOC). Activation of the AKT pathway promotes platinum resistance while inhibition of AKT sensitizes chemoresistant cells. Patients with BRCA mutant EOC, and thus a defect in the homologous recombinatio...

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Udgivet i:BMC Cancer
Main Authors: Whicker, Margaret E., Lin, Z. Ping, Hanna, Ruth, Sartorelli, Alan C., Ratner, Elena S.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4964088/
https://ncbi.nlm.nih.gov/pubmed/27465688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2598-1
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