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A phase I, placebo-controlled, randomized, double-blind, single ascending dose-ranging study to evaluate the safety and tolerability of a novel biophysical bronchodilator (S-1226) administered by nebulization in healthy volunteers

BACKGROUND: A major challenge in treating acute asthma exacerbations is the need to open constricted airways rapidly enough to reestablish ventilation and allow delivery of conventional medication to diseased airways. The solution requires a new approach that considers both biophysical and pharmacol...

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Bibliografske podrobnosti
izdano v:	Trials
Main Authors:	Green, Francis H. Y., Leigh, Richard, Fadayomi, Morenike, Lalli, Gurkeet, Chiu, Andrea, Shrestha, Grishma, ElShahat, Sharif G., Nelson, David Evan, El Mays, Tamer Y., Pieron, Cora A., Dennis, John H.
Format:	Artigo
Jezik:	Inglês
Izdano:	BioMed Central 2016
Teme:	Research
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4964056/ https://ncbi.nlm.nih.gov/pubmed/27464582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-016-1489-8
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A phase I, placebo-controlled, randomized, double-blind, single ascending dose-ranging study to evaluate the safety and tolerability of a novel biophysical bronchodilator (S-1226) administered by nebulization in healthy volunteers

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