Polygenic risk score is associated with increased disease risk in 52 Finnish breast cancer families

The risk of developing breast cancer is increased in women with family history of breast cancer and particularly in families with multiple cases of breast or ovarian cancer. Nevertheless, many women with a positive family history never develop the disease. Polygenic risk scores (PRSs) based on the r...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res Treat
Main Authors: Muranen, Taru A., Mavaddat, Nasim, Khan, Sofia, Fagerholm, Rainer, Pelttari, Liisa, Lee, Andrew, Aittomäki, Kristiina, Blomqvist, Carl, Easton, Douglas F., Nevanlinna, Heli
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2016
Assuntos:
Preclinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4963452/
https://ncbi.nlm.nih.gov/pubmed/27438779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-016-3897-6
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