RAD51, XRCC3, and XRCC2 mutation screening in Finnish breast cancer families

Majority of the known breast cancer susceptibility genes have a role in DNA repair and the most important high-risk genes BRCA1 and BRCA2 are specifically involved in the homologous recombination repair (HRR) of DNA double-strand breaks. A central player in HRR is RAD51 that binds DNA at the damage...

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Detalhes bibliográficos
Publicado no:Springerplus
Main Authors: Pelttari, Liisa M, Kiiski, Johanna I, Ranta, Salla, Vilske, Sara, Blomqvist, Carl, Aittomäki, Kristiina, Nevanlinna, Heli
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404470/
https://ncbi.nlm.nih.gov/pubmed/25918678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40064-015-0880-3
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