Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism

In mammals, hepatic lipid catabolism is essential for the newborns to efficiently use milk fat as an energy source. However, it is unclear how this critical trait is acquired and regulated. We demonstrate that under the control of PPARα, the genes required for lipid catabolism are transcribed before...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Rando, Gianpaolo, Tan, Chek Kun, Khaled, Nourhène, Montagner, Alexandra, Leuenberger, Nicolas, Bertrand-Michel, Justine, Paramalingam, Eeswari, Guillou, Hervé, Wahli, Walter
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2016
Fag:
Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4963200/
https://ncbi.nlm.nih.gov/pubmed/27367842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11853
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