GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation

BACKGROUND: After liver injury, the repair process comprises activation and proliferation of hepatic stellate cells (HSCs), which produce extracellular matrix (ECM) proteins. Peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) is highly expressed in these cells, but its function in liver...

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Detalhes bibliográficos
Main Authors: Kostadinova, Radina, Montagner, Alexandra, Gouranton, Erwan, Fleury, Sébastien, Guillou, Hervé, Dombrowicz, David, Desreumaux, Pierre, Wahli, Walter
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519722/
https://ncbi.nlm.nih.gov/pubmed/23046570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-3701-2-34
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