Bioautography with TLC-MS/NMR for Rapid Discovery of Anti-tuberculosis Lead Compounds from Natural Sources

While natural products constitute an established source of lead compounds, the classical iterative bioassay-guided isolation process is both time- and labor-intensive and prone to failing to identify active minor constituents. (HP)TLC-bioautography-MS/NMR, which combines cutting-edge microbiological...

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Publicat a:ACS Infect Dis
Autors principals: Grzelak, Edyta M., Hwang, Changhwa, Cai, Geping, Nam, Joo-Won, Choules, Mary P., Gao, Wei, Lankin, David C., McAlpine, James B., Mulugeta, Surafel G., Napolitano, José G., Suh, Joo-Won, Yang, Seung Hwan, Cheng, Jinhua, Lee, Hanki, Kim, Jin-Yong, Cho, Sang-Hyun, Pauli, Guido F., Franzblau, Scott G., Jaki, Birgit U.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4963014/
https://ncbi.nlm.nih.gov/pubmed/27478868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.5b00150
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