CD33-Targeted Lipid Nanoparticles (aCD33LNs) for Therapeutic Delivery of GTI-2040 to Acute Myelogenous Leukemia

CD33-targeted lipid nanoparticles (aCD33LNs) were synthesized for delivery of GTI-2040, an antisense oligonucleotide (ASO) against the R2 subunit of ribonucleotide reductase, to acute myelogenous leukemia (AML). These LNs incorporated a deoxycholate-polyethylenimine (DOC-PEI) conjugate, which has sh...

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Veröffentlicht in:Mol Pharm
Hauptverfasser: Li, Hong, Xu, Songlin, Quan, Jishan, Yung, Bryant C., Pang, Jiuxia, Zhou, Chenguang, Cho, Young-Ah, Zhang, Mengzi, Liu, Shujun, Muthusamy, Natarajan, Chan, Kenneth K., Byrd, John C., James Lee, L., Marcucci, Guido, Lee, Robert J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4962870/
https://ncbi.nlm.nih.gov/pubmed/25871632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp5008212
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