Metabolism of GTI-2040, a phosphorothioate oligonucleotide antisense, using ion-pair reversed phase high performance liquid chromatography (HPLC) coupled with electrospray ion-trap mass spectrometry

GTI-2040 is a 20-mer phosphorothioate oligonucleotide, which is complementary to the messenger ribonucleic acid (mRNA) of the R2 subunit of ribonucleotide reductase. This study characterized both the in vivo and in vitro metabolism of GTI-2040. A highly specific ion-pair reversed-phase electrospray...

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Hlavní autoři: Wei, Xiaohui, Dai, Guowei, Liu, Zhongfa, Cheng, Hao, Xie, Zhiliang, Marcucci, Guido, Chan, Kenneth K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer-Verlag 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2751371/
https://ncbi.nlm.nih.gov/pubmed/17285740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/aapsj080484
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