Thrombin Cleavage of Osteopontin Modulates Its Activities in Human Cells In Vitro and Mouse Experimental Autoimmune Encephalomyelitis In Vivo

Osteopontin is a proinflammatory cytokine and plays a pathogenetic role in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), by recruiting autoreactive T cells into the central nervous system. Osteopontin functions are modulated by thrombin cleavage generating...

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Publicado en:J Immunol Res
Autores principales: Boggio, Elena, Dianzani, Chiara, Gigliotti, Casimiro Luca, Soluri, Maria Felicia, Clemente, Nausicaa, Cappellano, Giuseppe, Toth, Erika, Raineri, Davide, Ferrara, Benedetta, Comi, Cristoforo, Dianzani, Umberto, Chiocchetti, Annalisa
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961817/
https://ncbi.nlm.nih.gov/pubmed/27478856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/9345495
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