Role of Anti-Osteopontin Antibodies in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

Osteopontin (OPN) is highly expressed in demyelinating lesions in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). OPN is cleaved by thrombin into N- (OPN-N) and C-terminal (OPN-C) fragments with different ligands and functions. In EAE, administering recombinant OPN induc...

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Publicado en:Front Immunol
Autores principales: Clemente, Nausicaa, Comi, Cristoforo, Raineri, Davide, Cappellano, Giuseppe, Vecchio, Domizia, Orilieri, Elisabetta, Gigliotti, Casimiro L., Boggio, Elena, Dianzani, Chiara, Sorosina, Melissa, Martinelli-Boneschi, Filippo, Caldano, Marzia, Bertolotto, Antonio, Ambrogio, Luca, Sblattero, Daniele, Cena, Tiziana, Leone, Maurizio, Dianzani, Umberto, Chiocchetti, Annalisa
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362623/
https://ncbi.nlm.nih.gov/pubmed/28386258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00321
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