Role of Anti-Osteopontin Antibodies in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

Osteopontin (OPN) is highly expressed in demyelinating lesions in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). OPN is cleaved by thrombin into N- (OPN-N) and C-terminal (OPN-C) fragments with different ligands and functions. In EAE, administering recombinant OPN induc...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Clemente, Nausicaa, Comi, Cristoforo, Raineri, Davide, Cappellano, Giuseppe, Vecchio, Domizia, Orilieri, Elisabetta, Gigliotti, Casimiro L., Boggio, Elena, Dianzani, Chiara, Sorosina, Melissa, Martinelli-Boneschi, Filippo, Caldano, Marzia, Bertolotto, Antonio, Ambrogio, Luca, Sblattero, Daniele, Cena, Tiziana, Leone, Maurizio, Dianzani, Umberto, Chiocchetti, Annalisa
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362623/
https://ncbi.nlm.nih.gov/pubmed/28386258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00321
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