Role of Anti-Osteopontin Antibodies in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

Osteopontin (OPN) is highly expressed in demyelinating lesions in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). OPN is cleaved by thrombin into N- (OPN-N) and C-terminal (OPN-C) fragments with different ligands and functions. In EAE, administering recombinant OPN induc...

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Bibliografski detalji
Izdano u:Front Immunol
Glavni autori: Clemente, Nausicaa, Comi, Cristoforo, Raineri, Davide, Cappellano, Giuseppe, Vecchio, Domizia, Orilieri, Elisabetta, Gigliotti, Casimiro L., Boggio, Elena, Dianzani, Chiara, Sorosina, Melissa, Martinelli-Boneschi, Filippo, Caldano, Marzia, Bertolotto, Antonio, Ambrogio, Luca, Sblattero, Daniele, Cena, Tiziana, Leone, Maurizio, Dianzani, Umberto, Chiocchetti, Annalisa
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2017
Teme:
Immunology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362623/
https://ncbi.nlm.nih.gov/pubmed/28386258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00321
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