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Osteopontin binds ICOSL promoting tumor metastasis
ICOSL/ICOS are costimulatory molecules pertaining to immune checkpoints; their binding transduces signals having anti-tumor activity. Osteopontin (OPN) is here identified as a ligand for ICOSL. OPN binds a different domain from that used by ICOS, and the binding induces a conformational change in OP...
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| Publicado no: | Commun Biol |
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| Main Authors: | , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7588454/ https://ncbi.nlm.nih.gov/pubmed/33106594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01333-1 |
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