SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein

Proteolytic generation of amyloidogenic amyloid β (Aβ) fragments from the amyloid precursor protein (APP) significantly contributes to Alzheimer's disease (AD). Although amyloidogenic APP proteolysis can be affected by trafficking through genetically associated AD components such as SORLA, how...

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Publicado en:J Neurosci
Main Authors: Huang, Timothy Y., Zhao, Yingjun, Li, Xiaoguang, Wang, Xin, Tseng, I-Chu, Thompson, Robert, Tu, Shichun, Willnow, Thomas E., Zhang, Yun-wu, Xu, Huaxi
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2016
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961782/
https://ncbi.nlm.nih.gov/pubmed/27466343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0206-16.2016
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