The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming

Amplified neuroinflammatory responses following an immune challenge occur with normal aging and can elicit or exacerbate neuropathology. The mechanisms mediating this sensitized or “primed” immune response in the aged brain are not fully understood. The alarmin high mobility group box 1 (HMGB1) can...

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發表在:J Neurosci
Main Authors: Fonken, Laura K., Frank, Matthew G., Kitt, Meagan M., D'Angelo, Heather M., Norden, Diana M., Weber, Michael D., Barrientos, Ruth M., Godbout, Jonathan P., Watkins, Linda R., Maier, Steven F.
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 2016
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961779/
https://ncbi.nlm.nih.gov/pubmed/27466339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1161-16.2016
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