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Promotion of Pro-Apoptotic Signals by Lysosomal Photodamage: Mechanistic Aspects and Influence of Autophagy

Prior studies demonstrated that a low level (LD(10–15)) of lysosomal photodamage can sensitize cells to the apoptotic death that results from subsequent mitochondrial photodamage. We have proposed that this process occurs via a calpain-catalyzed cleavage of the autophagy-associated protein ATG5 to f...

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Bibliographische Detailangaben
Veröffentlicht in:Photochem Photobiol
Hauptverfasser: Kessel, David, Evans, Conor L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961560/
https://ncbi.nlm.nih.gov/pubmed/27096545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/php.12592
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