The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

Tumour metastasis is a complex process involving reciprocal interplay between cancer cells and host stroma at both primary and secondary sites, and is strongly influenced by microenvironmental factors such as hypoxia1. Tumour-secreted proteins play a crucial role in these interactions2–5 and present...

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Publié dans:Nature
Auteurs principaux: Cox, Thomas R., Rumney, Robin M.H., Schoof, Erwin M., Perryman, Lara, Høye, Anette M., Agrawal, Ankita, Bird, Demelza, Latif, Norain Ab, Forrest, Hamish, Evans, Holly R., Huggins, Iain D, Lang, Georgina, Linding, Rune, Gartland, Alison, Erler, Janine T.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961239/
https://ncbi.nlm.nih.gov/pubmed/26017313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14492
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