Structure and function of the yeast listerin (Ltn1) conserved N-terminal domain in binding to stalled 60S ribosomal subunits

The Ltn1 E3 ligase (listerin in mammals) has emerged as a paradigm for understanding ribosome-associated ubiquitylation. Ltn1 binds to 60S ribosomal subunits to ubiquitylate nascent polypeptides that become stalled during synthesis; among Ltn1’s substrates are aberrant products of mRNA lacking stop...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Doamekpor, Selom K., Lee, Joong-Won, Hepowit, Nathaniel L., Wu, Cheng, Charenton, Clement, Leonard, Marilyn, Bengtson, Mario H., Rajashankar, Kanagalaghatta R., Sachs, Matthew S., Lima, Christopher D., Joazeiro, Claudio A. P.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961192/
https://ncbi.nlm.nih.gov/pubmed/27385828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605951113
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