Harnessing the Endocannabinoid 2-Arachidonoylglycerol to Lower Intraocular Pressure in a Murine Model

PURPOSE: Cannabinoids, such as Δ(9)-THC, act through an endogenous signaling system in the vertebrate eye that reduces IOP via CB(1) receptors. Endogenous cannabinoid (eCB) ligand, 2-arachidonoyl glycerol (2-AG), likewise activates CB(1) and is metabolized by monoacylglycerol lipase (MAGL). We inves...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Invest Ophthalmol Vis Sci
Main Authors: Miller, Sally, Leishman, Emma, Hu, Sherry Shujung, Elghouche, Alhasan, Daily, Laura, Murataeva, Natalia, Bradshaw, Heather, Straiker, Alex
Format: Artigo
Jezik:Inglês
Izdano: The Association for Research in Vision and Ophthalmology 2016
Teme:
Glaucoma
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961057/
https://ncbi.nlm.nih.gov/pubmed/27333182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.16-19356
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