miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)

BACKGROUND: Loss-of-function mutations in PINK1 and PARKIN are the most common causes of autosomal recessive Parkinson’s disease (PD). PINK1 is a mitochondrial serine/threonine kinase that plays a critical role in mitophagy, a selective autophagic clearance of damaged mitochondria. Accumulating evid...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Kim, Jaekwang, Fiesel, Fabienne C., Belmonte, Krystal C., Hudec, Roman, Wang, Wang-Xia, Kim, Chaeyoung, Nelson, Peter T., Springer, Wolfdieter, Kim, Jungsu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4960690/
https://ncbi.nlm.nih.gov/pubmed/27456084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0121-4
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