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Local administration of siRNA through Microneedle: Optimization, Bio-distribution, Tumor Suppression and Toxicity
Although RNA interference may become a novel therapeutic approach for cancer treatment, target-site accumulation of siRNA to achieve therapeutic dosage will be a major problem. Microneedle represents a better way to deliver siRNAs and we have evaluated for the first time the capability of a silicon...
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| Udgivet i: | Sci Rep |
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| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4960650/ https://ncbi.nlm.nih.gov/pubmed/27457182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30430 |
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