Production of full-length soluble Plasmodium falciparum RH5 protein vaccine using a Drosophila melanogaster Schneider 2 stable cell line system

The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) has recently emerged as a leading candidate antigen against the blood-stage human malaria parasite. However it has proved challenging to identify a heterologous expression platform that can produce a soluble protein-based vacci...

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Udgivet i:Sci Rep
Main Authors: Hjerrild, Kathryn A., Jin, Jing, Wright, Katherine E., Brown, Rebecca E., Marshall, Jennifer M., Labbé, Geneviève M., Silk, Sarah E., Cherry, Catherine J., Clemmensen, Stine B., Jørgensen, Thomas, Illingworth, Joseph J., Alanine, Daniel G. W., Milne, Kathryn H., Ashfield, Rebecca, de Jongh, Willem A., Douglas, Alexander D., Higgins, Matthew K., Draper, Simon J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4960544/
https://ncbi.nlm.nih.gov/pubmed/27457156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30357
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