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Coupling of the Non-Amyloid-Component (NAC) Domain and the KTK(E/Q)GV Repeats Stabilize the α-Synuclein Fibrils
The aggregates of α-synuclein (αS) are a major pathological hallmark of Parkinson’s disease (PD) making their structure-function relationship important for rational drug design. Yet, the atomic structure of the αS aggregates is unavailable, making it difficult to understand the underlying aggregatio...
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| 出版年: | Eur J Med Chem |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4960003/ https://ncbi.nlm.nih.gov/pubmed/26873872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.01.044 |
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