In permanent atrial fibrillation, PDE3 reduces force responses to 5‐HT, but PDE3 and PDE4 do not cause the blunting of atrial arrhythmias

BACKGROUND AND PURPOSE: 5‐HT increases force and L‐type Ca(2) (+) current (I(Ca,L)) and causes arrhythmias through 5‐HT(4) receptors in human atrium. In permanent atrial fibrillation (peAF), atrial force responses to 5‐HT are blunted, arrhythmias abolished but I(Ca,L) responses only moderately atten...

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Bibliographic Details
Published in:Br J Pharmacol
Main Authors: Berk, Emanuel, Christ, Torsten, Schwarz, Simon, Ravens, Ursula, Knaut, Michael, Kaumann, Alberto J
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959958/
https://ncbi.nlm.nih.gov/pubmed/27238373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13525
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