Efficacy of the nanoparticle–drug conjugate CRLX101 in combination with bevacizumab in metastatic renal cell carcinoma: results of an investigator-initiated phase I–IIa clinical trial

BACKGROUND: Anti-angiogenic therapies are effective in metastatic renal cell carcinoma (mRCC), but resistance is inevitable. A dual-inhibition strategy focused on hypoxia-inducible factor (HIF) is hypothesized to be active in this refractory setting. CRLX101 is an investigational camptothecin-contai...

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Bibliografiske detaljer
Udgivet i:Ann Oncol
Main Authors: Keefe, S. M., Hoffman-Censits, J., Cohen, R. B., Mamtani, R., Heitjan, D., Eliasof, S., Nixon, A., Turnbull, B., Garmey, E. G., Gunnarsson, O., Waliki, M., Ciconte, J., Jayaraman, L., Senderowicz, A., Tellez, A. B., Hennessy, M., Piscitelli, A., Vaughn, D., Smith, A., Haas, N. B.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959924/
https://ncbi.nlm.nih.gov/pubmed/27457310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdw188
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