Pilot trial of CRLX101 in patients with advanced, chemotherapy-refractory gastroesophageal cancer

BACKGROUND: CRLX101 is an investigational nanoparticle-drug conjugate with a camptothecin payload. Preclinical evidence indicated preferential uptake in tumors, and tumor xenograft models demonstrate superiority of CRLX101 over irinotecan. A pilot trial was conducted at recommended phase 2 dosing (R...

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Bibliografiske detaljer
Udgivet i:J Gastrointest Oncol
Main Authors: Chao, Joseph, Lin, James, Frankel, Paul, Clark, Andrew J., Wiley, Devin T., Garmey, Edward, Fakih, Marwan, Lim, Dean, Chung, Vincent, Luevanos, Eloise, Eliasof, Scott, Davis, Mark E., Yen, Yun
Format: Artigo
Sprog:Inglês
Udgivet: AME Publishing Company 2017
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750185/
https://ncbi.nlm.nih.gov/pubmed/29299355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/jgo.2017.08.10
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