Inactivation of oncogenic cAMP-specific phosphodiesterase 4D by miR-139-5p in response to p53 activation

Increasing evidence highlights the important roles of microRNAs in mediating p53’s tumor suppression functions. Here, we report miR-139-5p as another new p53 microRNA target. p53 induced the transcription of miR-139-5p, which in turn suppressed the protein levels of phosphodiesterase 4D (PDE4D), an...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Cao, Bo, Wang, Kebing, Liao, Jun-Ming, Zhou, Xiang, Liao, Peng, Zeng, Shelya X, He, Meifang, Chen, Lianzhou, He, Yulong, Li, Wen, Lu, Hua
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959878/
https://ncbi.nlm.nih.gov/pubmed/27383270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.15978
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