Statins increase hepatic cholesterol synthesis and stimulate fecal cholesterol elimination in mice

Statins are competitive inhibitors of HMG-CoA reductase, the rate-limiting enzyme of cholesterol synthesis. Statins reduce plasma cholesterol levels, but whether this is actually caused by inhibition of de novo cholesterol synthesis has not been clearly established. Using three different statins, we...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Schonewille, Marleen, Freark de Boer, Jan, Mele, Laura, Wolters, Henk, Bloks, Vincent W., Wolters, Justina C., Kuivenhoven, Jan A., Tietge, Uwe J. F., Brufau, Gemma, Groen, Albert K.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959861/
https://ncbi.nlm.nih.gov/pubmed/27313057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M067488
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