Internalization and presentation of myelin antigens by the brain endothelium guides antigen-specific T cell migration

Trafficking of myelin-reactive CD4(+) T-cells across the brain endothelium, an essential step in the pathogenesis of multiple sclerosis (MS), is suggested to be an antigen-specific process, yet which cells provide this signal is unknown. Here we provide direct evidence that under inflammatory condit...

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Udgivet i:eLife
Main Authors: Lopes Pinheiro, Melissa A, Kamermans, Alwin, Garcia-Vallejo, Juan J, van het Hof, Bert, Wierts, Laura, O'Toole, Tom, Boeve, Daniël, Verstege, Marleen, van der Pol, Susanne MA, van Kooyk, Yvette, de Vries, Helga E, Unger, Wendy WJ
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2016
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959842/
https://ncbi.nlm.nih.gov/pubmed/27336724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13149
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