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Liver-Specific Deletion of SRSF2 Caused Acute Liver Failure and Early Death in Mice
The liver performs a variety of unique functions critical for metabolic homeostasis. Here, we show that mice lacking the splicing factor SRSF2 but not SRSF1 in hepatocytes have severe liver pathology and biochemical abnormalities. Histological analyses revealed generalized hepatitis with the presenc...
Shranjeno v:
| izdano v: | Mol Cell Biol |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4959313/ https://ncbi.nlm.nih.gov/pubmed/27022105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01071-15 |
| Oznake: |
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