Loss of SRSF2 triggers hepatic progenitor cell activation and tumor development in mice

Splicing factor SRSF2 is frequently mutated or up-regulated in human cancers. Here, we observe that hepatocyte-specific deletion of Srsf2 trigger development of hepatocellular carcinoma (HCC) in mice, which also involves inflammation and fibrosis. Importantly, we find that, when compensatory hepatoc...

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Pubblicato in:Commun Biol
Autori principali: Zhang, Chang, Shen, Lei, Yuan, Wei, Liu, Yuguo, Guo, Ruochen, Luo, Yangjun, Zhan, Zheng, Xie, Zhiqin, Wu, Guohao, Wu, Wenwu, Feng, Ying
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7200752/
https://ncbi.nlm.nih.gov/pubmed/32372053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-0893-5
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