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Liver-Specific Deletion of SRSF2 Caused Acute Liver Failure and Early Death in Mice
The liver performs a variety of unique functions critical for metabolic homeostasis. Here, we show that mice lacking the splicing factor SRSF2 but not SRSF1 in hepatocytes have severe liver pathology and biochemical abnormalities. Histological analyses revealed generalized hepatitis with the presenc...
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| Publicado en: | Mol Cell Biol |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4959313/ https://ncbi.nlm.nih.gov/pubmed/27022105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01071-15 |
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