Redox Signaling and Bioenergetics Influence Lung Cancer Cell Line Sensitivity to the Isoflavone ME-344

ME-344 [(3R,4S)-3,4-bis(4-hydroxyphenyl)-8-methyl-3,4-dihydro-2H-chromen-7-ol] is a second-generation derivative natural product isoflavone presently under clinical development. ME-344 effects were compared in lung cancer cell lines that are either intrinsically sensitive or resistant to the drug an...

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Bibliographic Details
Published in:J Pharmacol Exp Ther
Main Authors: Manevich, Yefim, Reyes, Leticia, Britten, Carolyn D., Townsend, Danyelle M., Tew, Kenneth D.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2016
Subjects:
Chemotherapy, Antibiotics, and Gene Therapy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959101/
https://ncbi.nlm.nih.gov/pubmed/27255112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.229344
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