Voltage-Dependent Anion Channels Influence Cytotoxicity of ME-344, a Therapeutic Isoflavone

ME-344 is a second-generation cytotoxic isoflavone with anticancer activity promulgated through interference with mitochondrial functions. Using a click chemistry version of the drug together with affinity-enriched mass spectrometry, voltage-dependent anion channels (VDACs) 1 and 2 were identified a...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Zhang, Leilei, Townsend, Danyelle M., Morris, Morgan, Maldonado, Eduardo N., Jiang, Yu-Lin, Broome, Ann-Marie, Bethard, Jennifer R., Ball, Lauren E., Tew, Kenneth D.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2020
Assuntos:
Neuropharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7372917/
https://ncbi.nlm.nih.gov/pubmed/32546528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.120.000009
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