Voltage-dependent Anion Channels Modulate Mitochondrial Metabolism in Cancer Cells: REGULATION BY FREE TUBULIN AND ERASTIN

Respiratory substrates and adenine nucleotides cross the mitochondrial outer membrane through the voltage-dependent anion channel (VDAC), comprising three isoforms — VDAC1, 2, and 3. We characterized the role of individual isoforms in mitochondrial metabolism by HepG2 human hepatoma cells using siRN...

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Hauptverfasser: Maldonado, Eduardo N., Sheldon, Kely L., DeHart, David N., Patnaik, Jyoti, Manevich, Yefim, Townsend, Danyelle M., Bezrukov, Sergey M., Rostovtseva, Tatiana K., Lemasters, John J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636879/
https://ncbi.nlm.nih.gov/pubmed/23471966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.433847
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