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Erastin-Like Anti-Warburg Agents Prevent Mitochondrial Depolarization Induced by Free Tubulin and Decrease Lactate Formation in Cancer Cells

In Warburg metabolism, suppression of mitochondrial metabolism contributes to a low cytosolic ATP/ADP ratio favoring enhanced aerobic glycolysis. Flux of metabolites across the mitochondrial outer membrane occurs through voltage-dependent anion channels (VDAC). In cancer cells, free dimeric tubulin...

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Bibliografiska uppgifter
I publikationen:SLAS Discov
Huvudupphovsmän: DeHart, David N., Lemasters, John J., Maldonado, Eduardo N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927820/
https://ncbi.nlm.nih.gov/pubmed/29024608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555217731556
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