Loading...

Erastin-Like Anti-Warburg Agents Prevent Mitochondrial Depolarization Induced by Free Tubulin and Decrease Lactate Formation in Cancer Cells

In Warburg metabolism, suppression of mitochondrial metabolism contributes to a low cytosolic ATP/ADP ratio favoring enhanced aerobic glycolysis. Flux of metabolites across the mitochondrial outer membrane occurs through voltage-dependent anion channels (VDAC). In cancer cells, free dimeric tubulin...

Full description

Saved in:
Bibliographic Details
Published in:SLAS Discov
Main Authors: DeHart, David N., Lemasters, John J., Maldonado, Eduardo N.
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927820/
https://ncbi.nlm.nih.gov/pubmed/29024608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555217731556
Tags: Add Tag
No Tags, Be the first to tag this record!