Association of lymph-node antigens with lower Gag-specific central-memory and higher Env-specific effector-memory CD8(+) T-cell frequencies in a macaque AIDS model

Virus-specific CD8(+) T cells exert strong suppressive pressure on human/simian immunodeficiency virus (HIV/SIV) replication. These responses have been intensively examined in peripheral blood mononuclear cells (PBMCs) but not fully analyzed in lymph nodes (LNs), where interaction between CD8(+) T c...

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Pubblicato in:Sci Rep
Autori principali: Ishii, Hiroshi, Matsuoka, Saori, Nomura, Takushi, Nakamura, Midori, Shiino, Teiichiro, Sato, Yuko, Iwata-Yoshikawa, Naoko, Hasegawa, Hideki, Mizuta, Kazuta, Sakawaki, Hiromi, Miura, Tomoyuki, Koyanagi, Yoshio, Naruse, Taeko K., Kimura, Akinori, Matano, Tetsuro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958968/
https://ncbi.nlm.nih.gov/pubmed/27452272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30153
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