In vivo virulence of MHC-adapted AIDS virus serially-passaged through MHC-mismatched hosts

CD8(+) T-cell responses exert strong suppressive pressure on HIV replication and select for viral escape mutations. Some of these major histocompatibility complex class I (MHC-I)-associated mutations result in reduction of in vitro viral replicative capacity. While these mutations can revert after v...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: Seki, Sayuri, Nomura, Takushi, Nishizawa, Masako, Yamamoto, Hiroyuki, Ishii, Hiroshi, Matsuoka, Saori, Shiino, Teiichiro, Sato, Hironori, Mizuta, Kazuta, Sakawaki, Hiromi, Miura, Tomoyuki, Naruse, Taeko K., Kimura, Akinori, Matano, Tetsuro
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5624644/
https://ncbi.nlm.nih.gov/pubmed/28931083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006638
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