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Aberrant epilepsy-associated mutant Na(v)1.6 sodium channel activity can be targeted with cannabidiol

Mutations in brain isoforms of voltage-gated sodium channels have been identified in patients with distinct epileptic phenotypes. Clinically, these patients often do not respond well to classic anti-epileptics and many remain refractory to treatment. Exogenous as well as endogenous cannabinoids have...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Brain
मुख्य लेखकों: Patel, Reesha R., Barbosa, Cindy, Brustovetsky, Tatiana, Brustovetsky, Nickolay, Cummins, Theodore R.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2016
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958898/
https://ncbi.nlm.nih.gov/pubmed/27267376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/aww129
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