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Aberrant epilepsy-associated mutant Na(v)1.6 sodium channel activity can be targeted with cannabidiol
Mutations in brain isoforms of voltage-gated sodium channels have been identified in patients with distinct epileptic phenotypes. Clinically, these patients often do not respond well to classic anti-epileptics and many remain refractory to treatment. Exogenous as well as endogenous cannabinoids have...
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| Veröffentlicht in: | Brain |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4958898/ https://ncbi.nlm.nih.gov/pubmed/27267376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/aww129 |
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