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Inherent ER stress in Pancreatic Islet β cells Causes Self-Recognition by Autoreactive T Cells in Type 1 Diabetes
Type 1 diabetes (T1D) is an autoimmune disease characterized by pancreatic β cell destruction induced by islet reactive T cells that have escaped central tolerance. Many physiological and environmental triggers associated with T1D result in β cell endoplasmic reticulum (ER) stress and dysfunction, i...
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| Publicado no: | J Autoimmun |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4958612/ https://ncbi.nlm.nih.gov/pubmed/27173406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2016.04.009 |
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