Inherent ER stress in Pancreatic Islet β cells Causes Self-Recognition by Autoreactive T Cells in Type 1 Diabetes

Type 1 diabetes (T1D) is an autoimmune disease characterized by pancreatic β cell destruction induced by islet reactive T cells that have escaped central tolerance. Many physiological and environmental triggers associated with T1D result in β cell endoplasmic reticulum (ER) stress and dysfunction, i...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Autoimmun
Hauptverfasser: Marré, Meghan L., Profozich, Jennifer L., Coneybeer, Jorge T., Geng, Xuehui, Bertera, Suzanne, Ford, Michael J., Trucco, Massimo, Piganelli, Jon D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958612/
https://ncbi.nlm.nih.gov/pubmed/27173406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2016.04.009
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge