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Arrhythmogenic Calmodulin Mutations Impede Activation of Small-conductance Calcium-Activated Potassium Current
BACKGROUND: Apamin sensitive small-conductance Ca(2+)-activated K(+) (SK) channels are gated by intracellular Ca(2+) through a constitutive interaction with calmodulin. OBJECTIVE: We hypothesize that arrhythmogenic human calmodulin mutations impede activation of SK channels. METHODS: We studied 5 pr...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Heart Rhythm |
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| Κύριοι συγγραφείς: | , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2016
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4958519/ https://ncbi.nlm.nih.gov/pubmed/27165696 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2016.05.009 |
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