Arrhythmogenic Calmodulin Mutations Impede Activation of Small-conductance Calcium-Activated Potassium Current

BACKGROUND: Apamin sensitive small-conductance Ca(2+)-activated K(+) (SK) channels are gated by intracellular Ca(2+) through a constitutive interaction with calmodulin. OBJECTIVE: We hypothesize that arrhythmogenic human calmodulin mutations impede activation of SK channels. METHODS: We studied 5 pr...

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Publicado no:Heart Rhythm
Main Authors: Yu, Chih-Chieh, Ko, Jum-Suk, Ai, Tomohiko, Tsai, Wen-Chin, Chen, Zhenhui, Rubart, Michael, Vatta, Matteo, Everett, Thomas H., George, Alfred L., Chen, Peng-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958519/
https://ncbi.nlm.nih.gov/pubmed/27165696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2016.05.009
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