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Small Conductance Calcium-Activated Potassium Current is Activated During Hypokalemia and Masks Short Term Cardiac Memory Induced by Ventricular Pacing

BACKGROUND: Hypokalemia increases the vulnerability to ventricular fibrillation (VF). We hypothesize that the apamin-sensitive small conductance calcium-activated potassium current (I(KAS)) is activated during hypokalemia and that I(KAS) blockade is proarrhythmic. METHODS AND RESULTS: Optical mappin...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Chan, Yi-Hsin, Tsai, Wei-Chung, Ko, Jum-Suk, Yin, Dechun, Chang, Po-Cheng, Rubart, Michael, Weiss, James N., Everett, Thomas, Lin, Shien-Fong, Chen, Peng-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4605871/
https://ncbi.nlm.nih.gov/pubmed/26362634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.114.015125
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