Loading...
Molecular Basis for Redox Activation of Epidermal Growth Factor Receptor Kinase
EGFR is a target of signal-derived H(2)O(2) and oxidation of active site cysteine 797 to sulfenic acid enhances kinase activity. Although a major class of covalent drugs targets C797, nothing is known about its catalytic importance or how S-sulfenylation leads to activation. Here, we report the firs...
Saved in:
| Published in: | Cell Chem Biol |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
|
| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4958504/ https://ncbi.nlm.nih.gov/pubmed/27427230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.05.017 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|