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Molecular Basis for Redox Activation of Epidermal Growth Factor Receptor Kinase
EGFR is a target of signal-derived H(2)O(2) and oxidation of active site cysteine 797 to sulfenic acid enhances kinase activity. Although a major class of covalent drugs targets C797, nothing is known about its catalytic importance or how S-sulfenylation leads to activation. Here, we report the firs...
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| Pubblicato in: | Cell Chem Biol |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4958504/ https://ncbi.nlm.nih.gov/pubmed/27427230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.05.017 |
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