Efavirenz and Metabolites in Cerebrospinal Fluid: Relationship with CYP2B6 c.516G→T Genotype and Perturbed Blood-Brain Barrier Due to Tuberculous Meningitis

Efavirenz (EFZ) has been associated with neuropsychiatric side effects. Recently, the 8-hydroxy-EFZ (8OH-EFZ) metabolite has been shown to be a potent neurotoxin in vitro, inducing neuronal damage at concentrations of 3.3 ng/ml. EFZ induced similar neuronal damage at concentrations of 31.6 ng/ml. We...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Antimicrob Agents Chemother
Glavni autori: Nightingale, Sam, Chau, Tran Thi Hong, Fisher, Martin, Nelson, Mark, Winston, Alan, Else, Laura, Carr, Daniel F., Taylor, Steven, Ustianowski, Andrew, Back, David, Pirmohamed, Munir, Solomon, Tom, Farrar, Jeremy, Törok, M. Estée, Khoo, Saye
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2016
Teme:
Pharmacology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958147/
https://ncbi.nlm.nih.gov/pubmed/27161633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00280-16
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items