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Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort

OBJECTIVES: Efavirenz is extensively metabolized by CYP2B6, and associations between CYP2B6 polymorphisms and plasma efavirenz exposure have been reported. The objective of this study was to investigate CYP2B6 haplotype structure and functional consequences in a Latin American population. PATIENTS A...

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Detalhes bibliográficos
Main Authors: Carr, Daniel F., la Porte, Charles J. L., Pirmohamed, Munir, Owen, Andrew, Cortes, Claudia P.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920179/
https://ncbi.nlm.nih.gov/pubmed/20639527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkq260
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