Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort

OBJECTIVES: Efavirenz is extensively metabolized by CYP2B6, and associations between CYP2B6 polymorphisms and plasma efavirenz exposure have been reported. The objective of this study was to investigate CYP2B6 haplotype structure and functional consequences in a Latin American population. PATIENTS A...

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Autori principali: Carr, Daniel F., la Porte, Charles J. L., Pirmohamed, Munir, Owen, Andrew, Cortes, Claudia P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2010
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920179/
https://ncbi.nlm.nih.gov/pubmed/20639527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkq260
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